Maria S. Remedi was born and raised in Argentina. She obtained a Clinical Biochemistry degree and a PharmD degree from the University of Cordoba in Argentina, and a Ph.D in Chemical Sciences degree from the same University. Dr Remedi initially joined the Cell Biology and Physiology Department at Washington University in St Louis (USA) as a post-doc and move up through the ranks to Instructor and Assistant Professor. In 2015 she joined the Department of Medicine at Washington University in St Louis, and in 2017 she became the Associate Director of the Metabolic Tissue Function Core of the Diabetes Research Center.
Dr. Remedi research focuses on how changes in blood glucose levels regulate insulin secretion from the pancreatic beta-cell, and how this process is impaired in diabetes. The ATP-sensitive potassium (KATP) channel is a critical link between glucose metabolism and insulin secretion. Gain- and loss-of-function mutations in KATP channel genes cause two opposite diseases: neonatal diabetes and congenital hyperinsulinism. Dr. Remedi research has made major breakthroughs in the filed by demonstrating an ‘inverse U’ model of progression from hyperinsulinism to diabetes, and by defining critical pathways leading to changes in pancreatic islet-identity in neonatal diabetes and reversibility of the process. These results challenged the current paradigm of permanent beta-cell damage in long-standing diabetes, with critical implications for therapeutic options. Her current research focus on depicting the underlying mechanisms, and temporal progression, of pre-diabetes to glucotoxicity and beta-cell failure in various forms of diabetes and devise the most appropriate therapies.
The Remedi lab is privileged to contribute to collaborative efforts with multiple groups nationally and internationally, hoping to elucidate the mechanisms involved in beta-cell dysfunction in human diabetes, with the expectation to improve treatments to prevent, delay or reverse these processes. Dr Remedi has been fortunate to receive numerous awards for her work.